KMnO₄-Mediated Oxidation as a Continuous Flow Process

Jörg Sedelmeier*, Steven V. Ley*, Ian R. Baxendale and Marcus Baumann*

*Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, U.K., Email: theitcch.cam.ac.uk

J. Sedelmeier, S. V. Ley, I. R. Baxendale, M. Baumann, Org. Lett., 2010, 12, 3618-3621.

DOI: 10.1021/ol101345z

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Abstract

In an efficient and easily scalable continuous flow transformation of alcohols and aldehydes to carboxylic acids and nitroalkane derivatives to the corresponding carbonyls and carboxylic acids using permanganate as the oxidant, the generation and downstream processing of MnO₂ slurries was not found to cause any blocking of the reactor when ultrasound pulses were applied to the flow system.

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Key Words

Nef Reaction, Carboxylic Acids, Potassium Permanganate, Flow Chemistry

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ID: J54-Y2010-2280