Organic Chemistry Portal



KMnO4-Mediated Oxidation as a Continuous Flow Process

Jörg Sedelmeier*, Steven V. Ley*, Ian R. Baxendale and Marcus Baumann*

*Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, U.K., Email:

J. Sedelmeier, S. V. Ley, I. R. Baxendale, M. Baumann, Org. Lett., 2010, 12, 3618-3621.

DOI: 10.1021/ol101345z

see article for more reactions


In an efficient and easily scalable continuous flow transformation of alcohols and aldehydes to carboxylic acids and nitroalkane derivatives to the corresponding carbonyls and carboxylic acids using permanganate as the oxidant, the generation and downstream processing of MnO2 slurries was not found to cause any blocking of the reactor when ultrasound pulses were applied to the flow system.

see article for more examples

Key Words

Nef Reaction, Carboxylic Acids, Potassium Permanganate, Flow Chemistry

ID: J54-Y2010-2280