Solution-phase parallel oxazole synthesis with TosMIC
Bheemashankar A. Kulkarnia and Arun Ganesan*
*Chemistry, University of Southampton, Highfield,
Southampton, UK, SO17 1BJ, Email: a.ganesan
soton.ac.uk
B. A. Kulkarnia, A. Ganesan, Tetrahedron Lett., 1999, 40, 5637-5638.
DOI: 10.1016/S0040-4039(99)01050-3
Abstract
A quaternary ammonium hydroxide ion exchange resin catalyzes the reaction of p-tolylsulfonylmethyl isocyanide (TosMIC) with aromatic aldehydes to give 5-aryloxazoles. The base and the p-tolylsulfinic acid byproduct can be removed by simple filtration, resulting in oxazoles in high yield and purity.
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Key Words
Supported reagents/reactions, combinatorial chemistry, isocyanides, oxazoles, Van Leusen Oxazole Synthesis
ID: J72-Y1999-0780
