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A General and Efficient Catalyst for Palladium-Catalyzed C-O Coupling Reactions of Aryl Halides with Primary Alcohols

Saravanan Gowrisankar, Alexey G. Sergeev, Pazhamalai Anbarasan, Anke Spannenberg, Helfried Neumann and Matthias Beller*

*Leibniz-Institut für Katalyse e.V. an der Universität Rostock, Albert-Einstein-Strasse 29a, 18059 Rostock, Germany, Email:

S. Gowrisankar, A. G. Sergeev, P. Anbarasan, A. Spannenberg, H. Neumann, M. Beller, J. Am. Chem. Soc., 2010, 132, 11592-11598.

DOI: 10.1021/ja103248d


Palladium-catalyzed reactions of aryl halides including activated, nonactivated, and (hetero)aryl bromides as well as aryl chlorides with primary alcohols gave the corresponding alkyl aryl ethers in high yield in the presence of a bulky di-1-adamantyl-substituted bipyrazolylphosphine ligand. Functionalizations of primary alcohols in the presence of secondary and tertiary alcohols proceed with excellent selectivity.

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Key Words

Aryl Ethers

ID: J48-Y2010-2350