Pd-Catalyzed Carbonylative Conjugate Addition of Dialkylzinc Reagents to Unsaturated Carbonyls
Daniel W. Custar, Hai Le and James P. Morken*
*Department of Chemistry, Merkert Chemistry Center, Boston
College, Chestnut Hill, Massachusetts 02467, Email: morken
bc.edu
D. W. Custar, H. Le, J. P. Morken, Org. Lett., 2010, 12, 3760-3763.
DOI: 10.1021/ol1013476
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Abstract
A Pd-catalyzed addition of organozinc reagents to enones in the presence of carbon monoxide provides 1,4-diketones in good yield. Cyclic and acyclic α,β-unsaturated ketones as well as aldehydes can be converted.
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Key Words
ID: J54-Y2010-2400
