Facile and Highly Efficient N-Formylation of Amines Using a Catalytic Amount of Iodine under Solvent-Free Conditions
Joong-Gon Kim, Doo Ok Jang*
*Department of Chemistry, Yonsei University, Wonju 220-710, South Korea, Email: dojangyonsei.ac.kr
J.-G. Kim, D. O. Jang, Synlett, 2010, 2093-2096.
A simple, practical, and catalytic method for the N-formylation in the presence of molecular iodine as a catalyst under solvent-free conditions is applicable to a wide variety of amines. α-Amino acid esters can be converted without epimerization.
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