Organic Chemistry Portal



Facile and Highly Efficient N-Formylation of Amines Using a Catalytic Amount of Iodine under Solvent-Free Conditions

Joong-Gon Kim, Doo Ok Jang*

*Department of Chemistry, Yonsei University, Wonju 220-710, South Korea, Email:

J.-G. Kim, D. O. Jang, Synlett, 2010, 2093-2096.

DOI: 10.1055/s-0030-1258518


A simple, practical, and catalytic method for the N-formylation in the presence of molecular iodine as a catalyst under solvent-free conditions is applicable to a wide variety of amines. α-Amino acid esters can be converted without epimerization.

see article for more examples

Key Words

amine, amides, N-formylation, formic acid, iodine catalysis, solvent-free, green chemistry

ID: J60-Y2010-2410