Facile Conversion of Thioamides into the Corresponding Amides in the Presence of Tetrabutylammonium Bromide
Kiyofumi Inamoto*, Mitsugu Shiraishi, Kou Hiroya, Takayuki Doi*
*Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3, Aoba, Aramaki, Aoba-ku, Sendai, 980-8578, Japan, Email: inamotomail.pharm.tohoku.ac.jp, doi_takamail.pharm.tohoku.ac.jp
K. Inamoto, M. Shiraishi, K. Hiroya, T. Doi, Synthesis, 2010, 3087-3090.
Desulfurization of thioamides was accomplished using a semicatalytic amount of Bu4NBr. The corresponding amides were obtained in high yields, with good functional group compatibility.
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desulfurization, thioamides, amides, tetrabutylammonium bromide - thioketones