Catalytic Asymmetric Protonation of α-Amino Acid-Derived Ketene Disilyl Acetals Using P-Spiro Diaminodioxaphosphonium Barfates as Chiral Proton
Daisuke Uraguchi, Natsuko Kinoshita and Takashi Ooi*
*Department of Applied Chemistry, Graduate School of
Engineering, Nagoya University, Nagoya 464−8603, Japan, Email: tooi
apchem.nagoya-u.ac.jp
D. Uraguchi, N. Kinoshita, T. Ooi, J. Am. Chem. Soc., 2010, 132, 12240-12242.
DOI: 10.1021/ja105945z
Abstract
Chiral diaminodioxaphosphonium salts can be used in catalytic amounts in a highly enantioselective protonation of α-amino acid-derived ketene disilyl acetals in the presence of 2,6-dimethylphenol as stoichiometric proton source.
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Key Words
α-amino acids, desilylation, organocatalysis
ID: J48-Y2010-2580
