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A Novel Indium-Catalyzed Three-Component Reaction: General and Efficient One-Pot Synthesis of Substituted Pyrroles

Min Lin*, Lu Hao, Rui-da Ma, Zhuang-ping Zhan

*Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, Fujian, P. R. of China, Email:

M. Lin, L. Hao, R.-d. Ma, Z.-p. Zhan, Synlett, 2010, 2345-2351.

DOI: 10.1055/s-0030-1258525


A convenient and general one-pot synthesis of substituted pyrroles from propargylic acetates, silyl enol ethers, and primary amines was catalyzed by indium trichloride. High yields of various pyrrole derivatives were obtained.

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Key Words

pyrroles, indium, one-pot reaction, propargylic acetatea, enoxysilanes

ID: J60-Y2010-2640