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One-Pot Tandem Approach for the Synthesis of Benzothiazoles from Benzyl Halides

Chen Zhu, Takahiko Akiyama*

*Department of Chemistry, Gakushuin University, 1-5-1, Mejiro, Toshima-ku, Tokyo 171-8588, Japan, Email:

C. Zhu, T. Akiyama, Synlett, 2010, 2345-2351.

DOI: 10.1055/s-0030-1258046


A one-pot tandem reaction of benzyl halides and o-aminobenzenethiol gives benzothiazoles in high chemical yields under mild conditions in DMSO in the absence of an additional oxidant. Both benzyl chlorides and bromides bearing a range of substituents proved to be suitable substrates.

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Key Words

benzothiazoles, benzyl halides, oxidation, one-pot, tandem reaction, DMSO

ID: J60-Y2010-2710