O-Silylative Passerini Reaction: A New One-Pot Synthesis of α-Siloxyamides

Takahiro Soeta*, Yuuki Kojima, Yutaka Ukaji and Katsuhiko Inomata*

*Division of Material Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma, Kanazawa 920-1192, Japan, Email: soetase.kanazawa-u.ac.jp, inomatase.kanazawa-u.ac.jp

T. Soeta, Y. Kojima, Y. Ukaji, K. Inomata, Org. Lett., 2010, 12, 4280-4283.

DOI: 10.1021/ol101763w

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Abstract

A new method for a highly effective addition of isocyanides to aldehydes proceeded smoothly in the presence of a silanol to give the corresponding α-siloxyamides in high yields. A wide range of aldehydes and isocyanides are applicable in this reaction.

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Key Words

Passerini Reaction, Multicomponent Reactions

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ID: J54-Y2010-2720