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Cooperative Catalysis with Metal and Secondary Amine: Synthesis of 2-Substituted Quinolines via Addition/Cycloisomerization Cascade

Nitin T. Patil* and Vivek S. Raut

*Organic Chemistry Division - II, Indian Institute of Chemical Technology, Hyderabad 500 607, India, Email:

N. T. Patil, V. S. Raut, J. Org. Chem., 2010, 75, 6961-6964.

DOI: 10.1021/jo101103a

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A cooperative catalytic system, consisting of CuI and pyrrolidine enables an efficient synthesis of 2-substituted quinolines. A combination of both catalysts is necessary; the use of either catalyst alone does not give the product.

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ID: J42-Y2010-2730