Pyridine 2,6-Dicarboxylic Acid as a Bifunctional Organocatalyst for Hydrophosphonylation of Aldehydes and Ketones in Water
Fatemeh Jahani, Behi Zamenian, Samad Khaksar, Mahmood Tajbakhsh*
*Department of Chemistry, University of Mazandaran, P.O. Box
453, Babolsar, Iran,
Email: tajbaksh
umz.ac.ir
F. Jahani, B. Zamenian, S. Khaksar, M. Taibakhsh, Synthesis, 2010, 3315-3318.
DOI: 10.1055/s-0030-1257866
Abstract
An organocatalytic, direct synthesis of α-hydroxy phosphonates via reaction of aldehydes and ketones with trimethylphosphite in the presence of catalytic amounts of pyridine 2,6-dicarboxylic acid in water is simple, cost-effective and environmentally benign.
see article for more examples
M. Tajbakhsh, A. Heydari, M. A. Khalilzadeh, M. M. Lakouraj, B. Zamenian, S. Khaksar, Synlett, 2007, 2347-2350.
Key Words
α-hydroxy phosphonates, organocatalysis, green chemistry, water, nucleophilic addition, Abramov reaction
ID: J66-Y2010-2680
