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Palladium-Catalyzed C-H Functionalization of Heteroarenes with Aryl Bromides and Chlorides

Shunsuke Tamba, Youhei Okubo, Shota Tanaka, Daiki Monguchi and Atsunori Mori

*Department of Chemical Science and Engineering, Kobe University, 1-1 Rokkodai, Nada, Kobe 657-8501, Japan, Email:

S. Tamba, Y. Okubo, S. Tanaka, D. Monguchi, A. Mori, J. Org. Chem., 2010, 75, 6998-7001.

DOI: 10.1021/jo101433g

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A palladium-catalyzed C-H arylation of electron-enriched heteroarenes with aryl bromides and aryl chlorides proceeds in the presence of LiO-t-Bu as a base. Differently substituted 2,5-diarylthiazoles can be obtained with the same catalyst system by switching the solvent and the amount of base.

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Key Words


ID: J42-Y2010-2800