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Chemoselective Esterification and Amidation of Carboxylic Acids with Imidazole Carbamates and Ureas

Stephen T. Heller and Richmond Sarpong*

*Department of Chemistry, University of California, Berkeley, California 94720, United States, Email:

S. T. Heller, R. Sarpong, Org. Lett., 2010, 12, 4572-4575.

DOI: 10.1021/ol1018882


Imidazole carbamates and ureas are chemoselective esterification and amidation reagents. A simple synthetic procedure allows the conversion of a wide variety of carboxylic acids to ester or amide analogues in high yields.

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Key Words

esterification, Weinreb amides

ID: J54-Y2010-2840