An Improved and Mild Wenker Synthesis of Aziridines
Xinyao Li, Ning Chen, Jiaxi Xu*
*State Key Laboratory of Chemical Resource Engineering,
Department of Organic Chemistry, Faculty of Science, Beijing University of
Chemical Technology, Beijing 100029, P. R. of China,
Email: jxxu
mail.buct.edu.cn
X. Li, N. Chen, J. Xu, Synthesis, 2010, 3423-3428.
DOI: 10.1055/s-0030-1257913
Abstract
Amino alcohols were converted into their hydrogen sulfates with chlorosulfonic acid. The sulfates were cyclized with sodium hydroxide, and even with non-nucleophilic sodium carbonate. This improved, mild variation of the typical Wenker synthesis is applicable to unstable amino alcohols in hot sulfuric acid and to unstable sulfates which favor elimination and hydroxide displacement in the presence of strong base.
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Key Words
amino alcohols, aziridines, hydrogen sulfates, Wenker synthesis
ID: J66-Y2010-2850
