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Asymmetric Synthesis of Indolines by Catalytic Enantioselective Reduction of 3H-Indoles

Magnus Rueping*, Claus Brinkmann, Andrey P. Antonchick and Iuliana Atodiresei

*Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, D-52074 Aachen, Germany, Email:

M. Rueping, C. Brinkmann, A. P. Antonchick, I. Atoresei, Org. Lett., 2010, 12, 4604-4607.

DOI: 10.1021/ol1019234


A Brønsted acid catalyzed transfer hydrogenation of indole derivatives with Hantzsch dihydropyridine as the hydrogen source enables an efficient synthesis of various optically active indolines with high enantioselectivities.

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Key Words

Indolines, Organocatalysis, Hantzsch Ester

ID: J54-Y2010-2890