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Nitroethane in Polyphosphoric Acid: A New Reagent for Acetamidation and Amination of Aromatic Compounds

Alexander V. Aksenov*, Nicolai A. Aksenov, Oleg N. Nadein, Inna V. Aksenova

*Stavropol State University, Pushkina St. 1, Stavropol 355009, Russian Federation, Email: k-biochem-orgstavsu.ru

A. V. Aksenov, N. A. Aksenov, O. N. Nadein, I. V. Aksenova, Synlett, 2010, 2628-2630.

DOI: 10.1055/s-0030-1258767


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Abstract

The reaction of aromatic compounds with nitroethane in polyphosphoric acid allows the synthesis of acetamides in good yields. The corresponding amines can be obtained in situ upon hydrolysis of the acetamides.

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Key Words

aromatic compounds, nitroethane, polyphosphoric acid, acetamidation, amination


ID: J60-Y2010-2910