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Cu(OTf)2-Mediated Chan-Lam Reaction of Carboxylic Acids to Access Phenolic Esters

Lingli Zhang, Guoying Zhang, Manli Zhang and Jiang Cheng*

*College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325027, People's Republic of China, Email:

L. Zhang, G. Zhang, M. Zhang, J. Cheng, J. Org. Chem., 2010, 75, 7472-7474.

DOI: 10.1021/jo101558s


A Cu(OTf)2-mediated Chan-Lam reaction of carboxylic acids with arylboronic acids is a facile and practical methodology to access phenolic esters in good yields. The procedure tolerates various functional groups, such as methoxycarbonyl, acetoxy, free phenolic hydroxyl, vinyl, nitro, trifluoromethyl, methoxyl, bromo, chloro, iodo, and acetyl groups.

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Key Words

Chan-Lam Coupling, Phenols, Esters

ID: J42-Y2010-3080