Chromatography-Free Wittig Reactions Using a Bifunctional Polymeric Reagent
Peter Shu-Wai Leung, Yan Teng and Patrick H. Toy*
*Department of Chemistry, The University of Hong Kong,
Pokfulam Road, Hong Kong, P. R. of China, Email: phtoy
hku.hk
P. S.-W. Leung, Y. Teng, P. H. Toy, Org. Lett., 2010, 12, 4996-4999.
DOI: 10.1021/ol1021614
see article for more reactions
Abstract
Phosphine and amine functionalized polystyrene was used in one-pot Wittig reactions with an aldehyde and either an α-halo-ester, -ketone, or -amide. Due to the heterogeneous nature of the polymer, the desired alkene product of these reactions could be isolated in excellent yield in essentially pure form after only filtration and solvent removal.
see article for more examples
While ads financed 62% of the published abstracts in 2024, donations allowed us to publish additional 12%. 26% of the abstracts have been published voluntarly. If you kindly donate, we can publish more freely accessible information and help the chemical community even more:
If you don't like pawalls or a flood of more and more advertising, then you can send a clear signal here!
Rasta Resin-PPh3 and its Use in Chromatography-Free Wittig Reactions
P. S.-W. Leung, Y. Teng, P. H. Toy, Synlett, 2010, 1997-2001.
Key Words
α,β-unsaturated esters, Wittig reaction
ID: J54-Y2010-3170
