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Direct Addition of Functionalized Organozinc Reagents to Carbon Dioxide, Ketones, and Aldehydes in the Presence of MgCl2

Sebastian Bernhardt, Albrecht Metzger, Paul Knochel*

*Ludwigs-Maximilians-Universität München, Department Chemie, Butenandtstraße 5-13, Haus F, 81377 München, Germany, Email:

S. Bernhardt, A. Metzger, P. Knochel, Synthesis, 2010, 3802-3810.

DOI: 10.1055/s-0030-1258314

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A variety of functionalized organozinc reagents undergo smooth addition reactions at ambient temperature to carbonyl compounds and carbon dioxide in the presence of stoichiometric amounts of MgCl2. Several reactions were performed on a large scale.

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Key Words

organozinc reagents, magnesium chloride, carbon dioxide, phenylacetic acid derivatives, addition reactions, alcohols, benzylic alcohols, carboxylic acids

ID: J66-Y2010-3230