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Fast, Efficient, Mild, and Metal-Free Synthesis of Pyrroles by Domino Reactions in Water

Magnus Rueping* and Alejandro Parra

*Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, D-52074 Aachen, Germany, Email:

M. Rueping, A. Parra, Org. Lett., 2010, 12, 5281-5283.

DOI: 10.1021/ol102247n (free Supporting Information)

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A fast, mild, and environmentally benign domino reaction enables an efficient reaction of (E)-β-bromonitrostyrenes with enaminones in water to afford pyrroles in excellent yields.

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Key Words

Pyrroles, Green Chemistry, Enaminones

ID: J54-Y2010-3250