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Copper-Catalyzed Synthesis of Quinazoline Derivatives via Ullmann-Type Coupling and Aerobic Oxidation

Chen Wang, Shangfu Li, Hongxia Liu, Yuyang Jiang and Hua Fu*

*Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, People's Republic of China, Email:

C. Wang, S. Li, H. Liu, Y. Jiang, H. Fu, J. Org. Chem., 2010, 75, 7936-7938.

DOI: 10.1021/jo101685d


A simple and efficient, ligand-free copper-catalyzed approach to quinazoline derivatives uses readily available substituted (2-bromophenyl)methylamines and amides as starting materials. The cascade reaction includes a sequential Ullmann-type coupling and aerobic oxidation and provides a convenient and practical strategy for the synthesis of quinazoline derivatives.

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Copper-Catalyzed Sequential N-Arylation and Aerobic Oxidation: Synthesis of Quinazoline Derivatives

Q. Liu, Y. Zhao, H. Fu, C. Cheng, Synlett, 2013, 24, 2089-2094.

Key Words


ID: J42-Y2010-3260