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Facile Preparation of Aryl Sulfides Using Palladium Catalysis under Mild Conditions

Tatsuo Okauchi*, Kouji Kuramoto, Mitsuru Kitamura

*Department of Applied Chemistry, Kyushu Institute of Technology, 1-1 Sensui-cho, Tobata, Kitakyushu, 804-8550, Japan, Email:

T. Okauchi, K. Kuramoto, M. Kitamura, Synlett, 2010, 2891-2894.

DOI: 10.1055/s-0030-1259012


A convenient method for C-S cross-coupling of aryl bromides with various thiols involves the use of a 1,1′-bis(diphenylphosphino)ferrocene (DPPF)-ligated palladium complex with N,N-diisopropylethylamine (DIPEA) as the base. This coupling tolerates a wide range of functional groups, including hydroxy, amino, cyano, nitro, formyl, and carboxyl groups.

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Key Words

palladium, thiols, cross-coupling, C-S bond formation, aryl sulfides

ID: J60-Y2010-3370