Iron-Mediated Radical Halo-Nitration of Alkenes
Tsuyoshi Taniguchi*, Tatsuya Fujii and Hiroyuki Ishibashi
*School of Pharmaceutical Sciences, Institute of Medical,
Pharmaceutical and Health Sciences, Kanazawa University, Kakuma-machi, Kanazawa
920-1192, Japan, Email: tsuyoshi
p.kanazawa-u.ac.jp
T. Taniguchi, T. Fuji, H. Ishibashi, J. Org. Chem., 2010, 75, 8126-8132.
DOI: 10.1021/jo101769d
Abstract
Radical halo-nitration of alkenes proceeds easily by radical addition of nitrogen dioxide generated by thermal decomposition of iron(III) nitrate nonahydrate and subsequent trapping of the resultant radical by a halogen atom in the presence of a halogen salt. Application of this method to synthesis of nitroalkenes is also described.
see article for more examples
Key Words
Nitration, Chlorination, Nitro Alkenes
ID: J42-Y2010-3390
