Bidentate P, N-P Ligand for Nickel-Catalyzed Cross-Coupling of Aryl or Benzyl Chlorides with ArMgX

Raju Ghosh and Amitabha Sarkar*

*Department of Organic Chemistry, Indian Association for the Cultivation of Science, Jadavpur, Kolkata 700032, India, Email: ocasiacs.res.in

R. Ghosh, A. Sarkar, J. Org. Chem., 2010, 75, 8283-8386.

DOI: 10.1021/jo1016458

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Abstract

A cross-coupling reaction of various aryl, heteroaryl, and benzyl chlorides with ArMgX is catalyzed by nickel in the presence of a bidentate phosphine ligand. The ligand is stable in air and forms a stable complex in situ upon reaction with Ni(CH₃CN)₂Cl₂.

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Key Words

Kumada Coupling, Benzylation, Arylation

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ID: J42-Y2010-3400