Copper-Catalyzed Intermolecular Oxidative [3 + 2] Cycloaddition between Alkenes and Anhydrides: A New Synthetic Approach to γ-Lactones
Liangbin Huang, Huanfeng Jiang*, Chaorong Qi and Xiaohang Liu
*School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, P. R. China, Email: jianghfscut.edu.cn
L. Huang, H. Jiang, C. Qi, X. Liu, J. Am. Chem. Soc., 2010, 132, 17652-17654.
DOI: 10.1021/ja108073k (free Supporting Information)
A new copper-catalyzed oxidative [3 + 2] cycloaddition of alkenes with anhydrides using oxygen as the sole oxidant affords γ-lactones in good to excellent yield. This catalyzed cyclization process has a broad substrate scope.
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