Rhodium-Catalyzed Selective anti-Markovnikov Addition of Carboxylic Acids to Alkynes
Alexandre Lumbroso, Nicolas R. Vautravers and Bernhard Breit*
*Institut für Organische Chemie und Biochemie, Freiburg
Institute for Advanced Studies (FRIAS), Albert-Ludwigs-Universität Freiburg,
Albertstrasse 21, 79104, Freiburg, Germany, Email: bernhard.breit
chemie.uni-freiburg.de
A. Lumbroso, N. R. Vautravers, B. Breit, Org. Lett., 2010, 12, 5498-5501.
DOI: 10.1021/ol102365e
Abstract
A rhodium-catalyzed, selective intermolecular anti-Markovnikov addition of carboxylic acids to terminal alkynes gives valuable Z-enol esters. The catalyst system is applicable to a broad substrate scope and displays a wide functional group tolerance.
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Key Words
Esters, Carbonyl Compounds, Enols
ID: J54-Y2010-3460
