TBHP/I₂-Mediated Domino Oxidative Cyclization for One-Pot Synthesis of Polysubstituted Oxazoles

Huanfeng Jiang*, Huawen Huang, Hua Cao and Chaorong Qi

*School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, P. R. China, Email: jianghfscut.edu.cn

H. Jiang, H. Huang, H. Cao, C. Qi, Org. Lett., 2010, 12, 5561-5563.

DOI: 10.1021/ol1023085

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Abstract

A facile one-pot, transition-metal-free process enables the synthesis of various polysubstituted oxazoles via t-BuOOH/I₂-mediated domino oxidative cyclization from readily available starting materials under mild conditions.

see article for more examples

proposed reaction pathway

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Key Words

Oxazoles, TBHP

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ID: J54-Y2010-3470