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Effects of a Flexible Alkyl Chain on an Imidazole Ligand for Copper-Catalyzed Mannich Reactions of Terminal Alkynes

Takaaki Okamura, Keisuke Asano, Seijiro Matsubara*

*Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Kyoutodaigaku-katsura, Nishikyo, Kyoto 615-8510, Japan, Email:

T. Okamura, K. Asano, S. Matsubara, Synlett, 2010, 3053-3056.

DOI: 10.1055/s-0030-1259069


Copper-catalyzed Mannich reactions of terminal alkynes and secondary amines with aqueous formaldehyde is accelerated by the use of a catalytic amount of an imidazole ligand carrying a long alkyl chain.

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Key Words

alkyl chain, imidazole, steric effect, copper, proparylamines

ID: J60-Y2010-3480