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Mo(CO)6-Mediated Carbamoylation of Aryl Halides

Wei Ren and Motoki Yamane*

*Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore 637371, Singapore, Email: yamanentu.edu.sg

W. Ren, M. Yamane, J. Org. Chem., 2010, 75, 8410-8415.

DOI: 10.1021/jo101611g (free Supporting Information)


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Abstract

In a simple, Mo-mediated carbamoylation reaction of aryl halides, the incorporation of carbon monoxide is so efficient that it requires only a slight excess amount of carbon monoxide in the form of its molybdenum complex, Mo(CO)6. The reaction is applicable for the synthesis of a wide variety of not only secondary and tertiary amides but also primary amides by using aqueous ammonia.


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Key Words

Carbonylation, Aminocarbonylation


ID: J42-Y2010-3540