Trimethylsilyl Chloride Promoted Selective Desulfurization of Thiocarbonyls to Carbonyls with Hydrogen Peroxide

Kiumars Bahrami*, Mohammad Mehdi Khodaei*, Maryam Tajik

*Department of Chemistry, Razi University, Kermanshah 67149-67346, Iran, Email: kbahrami2hotmail.com, mmkhodarazi.ac.ir

K. Bahrami, M. M. Khodaei, M. Tajik, Synthesis, 2010, 4282-4286.

DOI: 10.1055/s-0030-1258283

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Abstract

In the presence of hydrogen peroxide and trimethylsilyl chloride, thiocarbonyls desulfurize to the corresponding carbonyls in short reaction times with no side reactions and excellent selectivity. This process is a safe, operationally simple, and environmentally benign alternative for the desulfurization of thiocarbonyls.

see article for more examples

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Desulfurization of Thioamides into Amides with H₂O₂/ZrCl₄ Reagent System

K. Bahrami, M. M. Khodaei, Y. Tirandaz, Synthesis, 2009, 369-371.

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Key Words

protecting groups, thiocarbonyls, desulfurization, ketones, amides, esters, trimethylsilyl chloride, hydrogen peroxide

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ID: J66-Y2010-3580