Cross Metathesis of N-Allylamines and α,β-Unsaturated Carbonyl Compounds: A One-Pot Synthesis of Substituted Pyrroles
Syed Shafi, Mariusz Kędziorek, Karol Grela*
*Institute of Organic Chemistry, Polish Academy of Sciences,
Kasprzaka 44/52, 01-224 Warsaw, Poland, Email: klgrela
gmail.com
S. Shafi, M. Kędziorek, K. Grela, Synlett, 2011, 124-128.
DOI: 10.1055/s-0030-1259083
Abstract
A tandem reaction involving cross metathesis followed by concomitant cyclisation enables the synthesis of substituted pyrroles. Various protected electron-deficient N-allylamines reacted with α,β-unsaturated carbonyl compounds in the presence of Lewis acids under the cross metathesis conditions using a 2nd generation Hoveyda catalyst in order to form pyrroles.
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Key Words
ruthenium, catalysis, olefin metathesis, Lewis acids, pyrroles
ID: J60-Y2011-0060
