A Highly Diastereo- and Enantioselective Copper(I)-Catalyzed Henry Reaction Using a Bis(sulfonamide)-Diamine Ligand
Wei Jin, Xincheng Li and Boshun Wan*
*Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China, Email: bswandicp.ac.cn
W. Jin, X. Li, B. Wan, J. Org. Chem., 2011, 76, 484-491.
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A chiral bis(sulfonamide)-diamine ligand coordinated with Cu(I), catalyzes the enantioselective Henry reaction with excellent enantioselectivity. Moreover, with the assistance of pyridine, the system promotes the diastereoselective Henry reaction with various aldehyde substrates and gives the corresponding syn-selective adducts.
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