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Efficient Iron/Copper-Cocatalyzed O-Arylation of Phenols with Bromoarenes

Xiaoyan Liu, Songlin Zhang*

*Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science,, Suzhou University, Dushu Lake Campus, Suzhou, 215123, P. R. of China, Email:

Y. Liu, S. Zhang, Synlett, 2011, 268-272.

DOI: 10.1055/s-0030-1259291


Low catalytic amounts of CuI and Fe(acac)3 effectively promote a C-O cross-coupling reaction in the presence of K2CO3 as the base. A serious of diaryl ethers with different substitutents can be synthesized in very good yields. This efficient and economic method is attractive for applications on an industrial scale.

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Key Words

catalysis, iron, copper, diaryl ethers

ID: J60-Y2011-0180