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Copper-Catalyzed Oxidative Amination of Benzoxazoles via C-H and C-N Bond Activation: A New Strategy for Using Tertiary Amines as Nitrogen Group Sources

Shengmei Guo, Bo Qian, Yinjun Xie, Chungu Xia and Hanmin Huang*

*State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, 730000, P. R. China, Email:

S. Guo, B. Qian, C. Xia, H. Huang, Org. Lett., 2011, 13, 522-525.

DOI: 10.1021/ol1030298


A convenient, copper-catalyzed C-H and C-N bond activation enables an efficient and conceptually new method for oxidative amination of azoles with tertiary amines. This protocol can be performed in the absence of external base and only requires atmospheric oxygen as oxidant.

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Key Words

Benzoxazoles, Oxygen

ID: J54-Y2011-0260