Copper-Catalyzed Highly Regioselective Silylcupration of Terminal Alkynes to Form α-Vinylsilanes
Peng Wang, Xue-Liang Yeo and Teck-Peng Loh*
*Division of Chemistry and Biological Chemistry, School of
Physical and Mathematical Sciences, Nanyang Technological University, Singapore
637371, Email: teckpeng
ntu.edu.sg
P. Wang, X.-L. Yeo, T.-P. Loh, J. Am. Chem. Soc., 2011, 133, 1254-1256.
DOI: 10.1021/ja109464u
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Abstract
Copper(I) catalyzes a highly regioselective synthesis of branched vinylsilanes through silicon-copper additions to terminal alkynes using methanol as additive. The corresponding vinylsilanes were obtained with excellent branched to linear selectivity in good yields.
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Key Words
ID: J48-Y2011-0270
