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Redox-Neutral Atom-Economic Rhodium-Catalyzed Coupling of Terminal Alkynes with Carboxylic Acids Toward Branched Allylic Esters

Alexandre Lumbroso, Philipp Koschker, Nicolas R. Vautravers and Bernhard Breit*

*Institut fur Organische Chemie und Biochemie, Freiburg Institute for Advanced Studies (FRIAS), Albert-Ludwigs-Universitat Freiburg, Albertstrasse 21, 79104 Freiburg im Breisgau, Germany, Email:

A. Lumbroso, P. Koschker, N. R. Vautravers, B. Breit, J. Am. Chem. Soc., 2011, 133, 2386-2389.

DOI: 10.1021/ja1108613


A method for the preparation of a wide range of branched allylic esters from terminal alkynes proceeds via a redox-neutral propargylic CH activation employing a rhodium(I)/DPEphos catalyst.

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Key Words

Allylic Alcohols, Esters

ID: J48-Y2011-0420