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Cu-Catalyzed One-Pot Synthesis of Unsymmetrical Diaryl Thioethers by Coupling of Aryl Halides Using a Thiol Precursor

D. J. C. Prasad and Govindasamy Sekar*

*Department of Chemistry, Indian Institute of Technology Madras, Chennai, Tamil Nadu-600 036, India, Email:

D. J. C. Prasad, G. Sekar, Org. Lett., 2011, 13, 1008-1011.

DOI: 10.1021/ol103041s

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In an efficient Cu-catalyzed one-pot approach for the synthesis of unsymmetrical diaryl thioethers through a Cu-catalyzed double arylation, the aryl thiols are generated in situ from an easily available xanthate and aryl halides. This strategy was further successfully utilized for the synthesis of symmetrical diaryl thioethers, aryl alkyl thioethers, and benzothiazoles.

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Key Words

Diaryl Sulfides, Dithiocarbonates

ID: J54-Y2011-0490