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Synthesis of Amides via Palladium-Catalyzed Amidation of Aryl Halides

Huanfeng Jiang*, Bifu Liu, Yibiao Li, Azhong Wang and Huawen Huang

*School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, P. R. China, Email:

H. Jiang, B. Liu, Y. Li. A. Wang, H. Huang, Org. Lett., 2011, 13, 1028-1031.

DOI: 10.1021/ol103081y (free Supporting Information)

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A new and efficient palladium-catalyzed C-C coupling of aryl halides with isocyanides enables the synthesis of amides under mild conditions. This transformation could extend its use to the synthesis of natural products and significant pharmaceuticals.

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ID: J54-Y2011-0520