Synthesis of Amides via Palladium-Catalyzed Amidation of Aryl Halides
Huanfeng Jiang*, Bifu Liu, Yibiao Li, Azhong Wang and Huawen Huang
*School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, P. R. China, Email: jianghfscut.edu.cn
H. Jiang, B. Liu, Y. Li. A. Wang, H. Huang, Org. Lett., 2011, 13, 1028-1031.
DOI: 10.1021/ol103081y (free Supporting Information)
see article for more reactions
A new and efficient palladium-catalyzed C-C coupling of aryl halides with isocyanides enables the synthesis of amides under mild conditions. This transformation could extend its use to the synthesis of natural products and significant pharmaceuticals.
see article for more examples