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Facile Amide Formation via S-Nitrosothioacids

Jia Pan, Nelmi O. Devarie-Baez and Ming Xian

*Department of Chemistry, Washington State University, Pullman, Washington 99164, United States, Email: mxianwsu.edu

J. Pan, N. O. Devarie-Baez, M. Xian, Org. Lett., 2011, 13, 1092-1094.

DOI: 10.1021/ol1031393 (free Supporting Information)


Abstract

A novel amide bond formation strategy from simple thioacid and amine starting materials is mediated by unstable but very reactive S-nitrosothioacid intermediates. This fast reaction under mild conditions should be useful in synthesis.

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Key Words

Amides


ID: J54-Y2011-0550