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A Copper(I) Isonitrile Complex as a Heterogeneous Catalyst for Azide-Alkyne Cycloaddition in Water

Meina Liu and Oliver Reiser*

*Institut fur Organische Chemie, Universitat Regensburg, Universitatsstr. 31, 93053 Regensburg, Germany, Email:

M. Liu, O. Reiser, Org. Lett., 2011, 13, 1102-1105.

DOI: 10.1021/ol103134c


A well-defined copper(I) isonitrile complex is an efficient, heterogeneous catalyst for azide-alkyne cycloadditions and three-component reactions of halides, sodium azide and alkynes to form 1,4-disubstituted 1,2,3-triazoles in high yields under mild conditions in water. The complex can be recycled for at least five runs without significant loss of activity by simple precipitation and filtration.

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Key Words

Click Chemistry, Green Chemistry, Multicomponent Reactions, 1,2,3-Triazoles

ID: J54-Y2011-0570