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Integrated Catalytic C-H Transformations for One-Pot Synthesis of 1-Arylisoindoles from Isoindolines via Palladium-Catalyzed Dehydrogenation Followed by C-H Arylation

Toshimichi Ohmura*, Akihito Kijima and Michinori Suginome*

*Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto 615-8510, Japan, Email: ohmurasbchem.kyoto-u.ac.jp, suginomesbchem.kyoto-u.ac.jp

T. Ohmura, A. Kijima, M. Suginome, Org. Lett., 2011, 13, 1238-1241.

DOI: 10.1021/ol2001232


Abstract

A one-pot conversion of isoindolines to 1-arylisoindoles was established from palladium-catalyzed cascade C-H transformations. A dehydrogenation of isoindolines followod by C-H arylation of the isoindoles gives the desired 1-arylisoindoles in good yields.


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Key Words

Isoindoles, Cyclohexene


ID: J54-Y2011-0620