A Practical Synthesis of 2-Aroylindoles from N-(2-Formylphenyl)trifluoroacetamides in PEG-400
Yu Zhao, Deyao Li, Liwen Zhao, Jiancun Zhang*
*Guangzhou Institute of Biomedicine and Health, CAS, 190 Kai Yuan Avenue, Science Park, Guangzhou 510530, P. R. of China, Email: zhang_jiancungibh.ac.cn
Y. Zhao, D. Li, L. Zhao, J. Zhang, Synthesis, 2011, 873-880.
The reaction of easily accessible N-(2-formylphenyl)trifluoroacetamides and α-bromoacetophenones in the presence of K2CO3 enables a one-pot and environmentally benign approach to the synthesis of highly functionalized 3-unsubstituted 2-aroylindoles. PEG-400 is an efficient and reusable solvent in this process.
see article for more examples