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Palladium-Catalyzed Intramolecular Trapping of the Blaise Reaction Intermediate for Tandem One-Pot Synthesis of Indole Derivatives

Ju Hyun Kim and Sang-gi Lee

*Department of Chemistry and Nano Science (BK21), Ewha Womans University, Seoul 120-750, Korea, Email: sanggiewha.ac.kr

J. H. Kim, S.-g. Lee, Org. Lett., 2011, 13, 1350-1353.

DOI: 10.1021/ol200045q


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Abstract

Palladium-catalyzed intramolecular N-arylative and N-alkylative/N-arylative trappings of the Blaise reaction intermediates enable the construction of the indole moiety in a tandem one-pot manner from nitriles.

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Key Words

Blaise Reaction, Indoles


ID: J54-Y2011-0710