Asymmetric Direct Michael Addition of Acetophenone to α,β-Unsaturated Aldehydes

Wenjun Li, Wenbin Wu, Juanjuan Yang, Xinmiao Liang, Jinxing Ye*

*Engineering Research Centre of Pharmaceutical Process Chemistry, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, P. R. of China, Email: yejxecust.edu.cn

W. Li, W. Wu, J. Yang, X. Liang, J. Ye, Synthesis, 2011, 1085-1091.

DOI: 10.1055/s-0030-1258459

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Abstract

An asymmetric direct Michael addition of α,β-unsaturated aldehydes with acetophenone catalyzed by a Jørgensen-Hayashi catalyst in methanol gave δ-keto aldehydes in up to 82% yield and 98% ee.

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Key Words

1,5-Diketones, Michael Addition, Organocatalysis, Asymmetric Catalysis, Ketones, Aldehydes, Enals

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ID: J66-Y2011-0920