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Gold-Catalyzed Direct Amination of Arenes with Azodicarboxylates

Liuqun Gu, Boon Siong Neo and Yugen Zhang

*Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, the Nanos, Singapore 138669, Email:

L. Gu, B. S. Neo, Y. Zhang, Org. Lett., 2011, 13, 1872-1874.

DOI: 10.1021/ol200373q (free Supporting Information)

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A gold(III) chloride catalyzed direct amination of arenes with azodicarboxylates allows the conversion of a broad range of substrates, including electron-deficient arenes, under mild conditions. This reaction provides an important approach for the synthesis of heterocyclic compounds in pharmaceutical and chemical industries.

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Key Words


ID: J54-Y2011-0930