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Borrowing Hydrogen Methodology for Amine Synthesis under Solvent-Free Microwave Conditions

Andrew J. A. Watson, Aoife C. Maxwell and Jonathan M. J. Williams*

*Department of Chemistry, University of Bath, Claverton Down, Bath BA2 7AY, U.K., Email:

A. J. A. Watson, A. C. Maxwell, J. M. J. Williams, J. Org. Chem., 2011, 76, 2328-2331.

DOI: 10.1021/jo102521a

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Microwave heating enables a Borrowing Hydrogen strategy to form C-N bonds from alcohols and amines, removes the need for solvent and reduces the reaction times, while the results are comparable with those using thermal heating.

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Ruthenium-Catalyzed N-Alkylation of Amines and Sulfonamides Using Borrowing Hydrogen Methodology

M. H. S. A. Hamid, C. L. Allen, G. W. Lamb, A. C. Maxwell, H. C. Maytum, A. J. A. Watson, J. M. J. Williams, J. Am. Chem. Soc., 2009, 131, 1766-1774.

Key Words

Amines, Cyclic Amines, Sulfonamides, Microwave Synthesis, Green Chemistry

ID: J42-Y2011-0940