Borrowing Hydrogen Methodology for Amine Synthesis under Solvent-Free Microwave Conditions
Andrew J. A. Watson, Aoife C. Maxwell and Jonathan M. J. Williams*
*Department of Chemistry, University of Bath, Claverton Down, Bath BA2 7AY, U.K., Email: j.m.j.williamsbath.ac.uk
A. J. A. Watson, A. C. Maxwell, J. M. J. Williams, J. Org. Chem., 2011, 76, 2328-2331.
DOI: 10.1021/jo102521a (free Supporting Information)
see article for more reactions
Microwave heating enables a Borrowing Hydrogen strategy to form C-N bonds from alcohols and amines, removes the need for solvent and reduces the reaction times, while the results are comparable with those using thermal heating.
see article for more examples
M. H. S. A. Hamid, C. L. Allen, G. W. Lamb, A. C. Maxwell, H. C. Maytum, A. J. A. Watson, J. M. J. Williams, J. Am. Chem. Soc., 2009, 131, 1766-1774.