Borrowing Hydrogen Methodology for Amine Synthesis under Solvent-Free Microwave Conditions
Andrew J. A. Watson, Aoife C. Maxwell and Jonathan M. J. Williams*
*Department of Chemistry, University of Bath, Claverton Down, Bath BA2 7AY, U.K., Email: j.m.j.williamsbath.ac.uk
A. J. A. Watson, A. C. Maxwell, J. M. J. Williams, J. Org. Chem., 2011, 76, 2328-2331.
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Microwave heating enables a Borrowing Hydrogen strategy to form C-N bonds from alcohols and amines, removes the need for solvent and reduces the reaction times, while the results are comparable with those using thermal heating.
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M. H. S. A. Hamid, C. L. Allen, G. W. Lamb, A. C. Maxwell, H. C. Maytum, A. J. A. Watson, J. M. J. Williams, J. Am. Chem. Soc., 2009, 131, 1766-1774.