Palladium-Catalyzed Monoarylation of Aryl Amine with Aryl Tosylates
Xiaomin Xie*, Gang Ni, Fangfang Ma, Lina Ding, Sheng Xu, Zhaoguo Zhang
*School of Chemistry and Chemical Engineering, Shanghai Jiao
Tong University, 800 Dongchuan Road, Shanghai 200240,P. R. of China, Email:
xiaominxie
sjtu.edu.cn
X. Xie, G. Ni, F. Ma, L. Ding, S. Xu, Z. Zhang, Synlett, 2011, 955-958.
DOI: 10.1055/s-0030-1259728
see article for more reactions
Abstract
In the presence of Pd(OAc)2, PhB(OH)2, and a hindered and electron-rich MOP-type ligand, a variety of primary aryl amines reacted with various aryl tosylates to form the corresponding secondary aryl amines in high yields with high selectivity. Furthermore, the catalyst system was also efficient for the arylation of indoles and hydrazones with aryl tosylates.
see article for more examples
Key Words
palladium, ligand, monoarylation, aryl tosylates, aryl amines, Buchwald-Hartwig Coupling
ID: J60-Y2011-0980
