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Highly Chemoselective Esterification Reactions and Boc/THP/TBDMS Discriminating Deprotections under Samarium(III) Catalysis

Pushparathinam Gopinath, Surapaneni Nilaya and Kannoth Manheri Muraleedharan*

*Department of Chemistry, Indian Institute of Technology Madras, Chennai, 600 036, India, Email: mkmiitm.ac.in

P. Gopinath, S. Nilaya, K. M. Muraleedharan, Org. Lett., 2011, 13, 1932-1935.

DOI: 10.1021/ol200247c (free Supporting Information)


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Abstract

SmCl3 is an excellent catalyst for chemoselective esterifications and selective removal of acid sensitive hydroxyl protecting groups such as Boc, THP, and TBDMS. Chemoselective deprotection is demonstrated through suitable examples.

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Key Words

Boc-protected amines


ID: J54-Y2011-1010