[CuBr(PPh₃)₃] for Azide-Alkyne Cycloaddition Reactions under Strict Click Conditions

Steven Lal and Silvia Díez-González*

*Department of Chemistry, Imperial College London, Exhibition Road, South Kensington, London SW7 2AZ, U.K., Email: s.diez-gonzalezimperial.ac.uk

S. Lal, S. Díez-González, J. Org. Chem., 2011, 76, 2367-2373.

DOI: 10.1021/jo200085j

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Abstract

A true Click catalytic system is based on commercially available [CuBr(PPh₃)₃]. This system is active at room temperature, with catalyst loadings of 0.5 mol % or less, in the absence of any additive, and it does not require any purification step to isolate pure triazoles.

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Key Words

Click Chemistry, Multicomponent Reactions, Green Chemistry, 1,2,3-Triazoles

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ID: J42-Y2011-1020